A02
Impact of neonatal CMV infection on lung macrophage development
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We recently discovered that cytomegalovirus (CMV) remodels the identity of fully differentiated alveolar macrophages. This project combines this knowledge with insights into how chronic infections manipulate macrophage progenitors.
We explore how perinatal CMV infections impact on innate cellular barrier immunity. A particular focus is on renewal and function of resident lung macrophage subsets, and thus on immunity to bacterial pneumonia later in life.
Team
Publications
Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interfaceMansoori Moghadam Z, Zhao B, Raynaud C, Strohmeier V, Neuber J, Lösslein AK, Qureshi S, Gres V, Ziegelbauer T, Baasch S, Schell C, Warnatz K, Inohara N, Nunez G, Clavel T, Rosshart SP, Kolter J, Henneke P. |
Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment |
Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
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