Project Area A: Response to exogenous cues

This project explores the hypothesis that postnatal development of γδ T cells and Langerhans cells (LC) in epidermis and oral mucosa is highly dependent on the dynamic interplay of these two resident immune cells within the perinatal time window.

We aim to define the differentiation dynamics and molecular crosstalk between γδ T cells and LC in two distinct tissue niches. Moreover, we explore the role of microbial colonization during γδ T cell/LC differentiation and adaptation.