Perinatal crosstalk of microbiota and intestinal macrophages in the control of mucosal pathogens
Our project explores the co-development of the neonatal microbiota and intestinal Mφ. We focus on metabolic programming and epigenetic imprinting in the integration of potentially highly pathogenic mucosal colonizers, in particular streptococci, into the host-adapted microbiota. We examine molecular and cellular mechanisms underlying co-evolution of a stable intestinal host-microbe interface.
Team
Publications
M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patchTorow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW 2023 Immunity
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Early life gut microbiota profiles linked to synbiotic formula effects: a randomized clinical trial in European infantsIlias Lagkouvardos, Evangelia Intze, Monika Schaubeck, James PK. Rooney, Christina Hecht, Hugues Piloquet, Thomas Clavel 2022 Am J Clin Nutr
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Meconium Microbiome of Very Preterm Infants across GermanyJonas Klopp, Pamela Ferretti, Claudius U. Meyer, Katja Hilbert, Annette Haiß, Janina Marißen, Philipp Henneke, Hannes Hudalla, Sabine Pirr, Dorothee Viemann, Michael Zemlin, Sofia Kirke Forslund, Christoph Härtel, Peer Bork, Stephan Gehring, Thea Van Rossum, and the PRIMAL Consortium and Vincent B. Young |
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease |
Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
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