The role of S100-alarmins in the perinatal development of respiratory immunity
S100-alarmins are endogenous factors that tune systemic and gut immunity after birth, thereby ensuring immune adaptation to the environment. Our project explores the role of S100A8/A9 in the perinatal development of lung and airway immunity.
We focus on neonatal and long-term programming of epithelial cells and cross-talk with professional immune cells, platelets and the vascular system. We also elucidate the cellular source of S100A8/A9 in the amniotic fluid by investigating non-immune cells in the lung.
Team
Publications
Neonatal liver niches program T cell toleranceEva-Lena Stange, Trong-Hieu Nguyen, Dustyn Mendoza, Aiara Lobo Gomes, Marlene Sophia Kohlhepp, Jonas Pes, Shahed Al Bounny, Julian Brueck, Yunus Cetiner, Urs Moerbe, Milas Ugur, Cristina Kalbermatter, Jarrett Lopez-Scarim, Aline Dupont, Susan A. V. Jennings, Julia Heckmann, Aaron Silva-Sanchez, Solveig Runge, Christoph Kuppe, Oliver Pabst, Thomas Clavel, Dorothee Viemann, Stephan P. Rosshart, Vuk Cerovic, Stephanie C. Ganal-Vonarburg, Adrien Guillot, Eva Billerbeck, Mathias W. Hornef, Natalia Torow |
Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birthEhlers G, Tödtmann AM, Holsten L, Willers M, Heckmann J, Schöning J, Richter M, Heinemann AS, Pirr S, Heinz A, Dopfer C, Händler K, Becker M, Büchel J, Wöckel A, von Kaisenberg C, Hansen G, Hiller K, Schultze JL, Härtel C, Kastenmüller W, Vaeth M, Ulas T, Viemann D. 2025 Nature Communications
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Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a humanized mouse modelJustine Smout, Till Robin Lesker, Lisa Hoenicke, Diego Ortiz, Mangge Zou, Friederike Kruse, Sabine Pirr, Maike Willers, Christoph Härtel, Christine Falk, Natalia Torow, Dorothee Viemann, Till Strowig, Jochen Huehn
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γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsisLeón-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L, Schöning J, Harms A, Almeida V, Schimrock A, Janssen A, Ospina-Quintero L, von Kaisenberg C, Förster R, Eberl M, Richter MF, Pirr S, Viemann D, Ravens S. 2024 Journal of Experimental Medicine
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A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI)Hartmann CR, Khan R, Schöning J, Richter M, Willers M, Pirr S, Heckmann J, Dirks J, Morbach H, Konrad M, Fries E, Winkler M, Büchel J, Seidenspinner S, Fischer J, Vollmuth C, Meinhardt M, Marissen J, Schmolke M, Haid S, Pietschmann T, Backes S, Dölken L, Löber U, Keil T, Heuschmann PU, Wöckel A, Sagar, Ulas T, Forslund-Startceva SK, Härtel C, Viemann D. 2024 Frontiers in Immunology
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Postnatal supplementation with alarmins S100a8/a9 ameliorates malnutrition-induced neonate enteropathy in micePerruzza L, Heckmann J, Rezzonico Jost T, Raneri M, Guglielmetti S, Gargari G, Palatella M, Willers M, Fehlhaber B, Werlein C, Vogl T, Roth J, Grassi F, Viemann D 2024 Nature Communications
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Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationPekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K. 2023 Immunity
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