Publications

Jagunal homolog 1 safeguards neutrophil immune function by preserving protein sialylation during differentiation

Katrin Nussbaumer, Max Hübner, Raul da Costa, Daniel Petersheim, Monika I. Linder, Julia Krebs, Matteo Napoli, Bastian Popper, Jiakuan Zhao, Mathis Richter, Almke Bader, Annette Zehrer, Dorothee Gössel, Thomas Vogl, Johannes Roth, Barbara Walzog, Simone Kreth, Oliver Soehnlein, Gerald Wirnsberger, Roland Immler, Josef M. Penninger, Jamey D. Marth, Christoph Klein, Markus Sperandio

2026 Blood Advances
https://doi.org/10.1182/bloodadvances.2026019794

Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression

Nour Diab, Chiun Huei Yong, Eva-Lena Stange, Marlène S. Birk, Matthias A. Schmitz, Stefan Düsterhöft, Jonas Pes, Kira Noemi Ferle, Isabel Karkossa, Kristin Schubert, Jörg Deiwick, Mihael Vucur, Tom Luedde, Natalia Torow, Andreas Ludwig, Aline Dupont, Joel Selkrig, Martin von Bergen, Michael Hensel, Kaiyi Zhang & Mathias W. Hornef

2026 Nature Communications
https://doi.org/10.1038/s41467-026-74942-9

Neutrophils are critical for placental and fetal infection with the human pathogen Listeria monocytogenes

Myriam Ripphahn, Nikita Raj, Hellen Ishikawa-Ankerhold, Zhouyi Rong, Bastian Popper, Bianca Portugal Tavares de Moraes, Xia Li, Ying Chen, Roland Immler, Lou-Martha Wackerbarth, Dominic van den Heuvel, Barbara Schmidinger, Rainer Haas, Udo Jeschke, Sven Kehl, Anne Loesslein, Steffen Massberg, Farida Hellal, Ali Ertürk, Markus Sperandio

2026 BioRxiv
https://doi.org/10.64898/2026.03.16.712023

Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancy

Roland Immler, Wiebke Nadolni, Johanna M Franz, Annika Bertsch, Sebastian Baasch, Vasilios A Morikis, Aleksandra Kurova, Marco Borso, Ignasi Forné, Ericka C M Itang, Johannes B Müller-Reif, Monika Pruenster, Lou M Wackerbarth, Matteo Napoli, Ina Rohwedder, Anna Yevtushenko, Michael Rauer, Martin Kolben, Markus Moser, Eytan Barnea, Melanie Boerries, Thomas Vogl, Scott I Simon, Claudia Klein, Philipp Henneke, Axel Imhof, Susanna Zierler, Markus Sperandio

2026 BioRxiv
https://doi.org/10.64898/2026.03.20.713251

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation

Monika Pruenster, Roland Immler, Jonas Roth, Tim Kuchler, Thomas Bromberger, Matteo Napoli, Katrin Nussbaumer, Ina Rohwedder, Lou Martha Wackerbarth, Chiara Piantoni, Konstantin Hennis, Diana Fink, Sebastian Kallabis, Tobias Schroll, Sergi Masgrau-Alsina, Agnes Budke, Wang Liu, Dietmar Vestweber, Christian Wahl-Schott, Johannes Roth, Felix Meissner, Markus Moser, Thomas Vogl, Veit Hornung, Petr Broz & Markus Sperandio

2023 Nature Immunology
https://doi.org/10.1038/s41590-023-01656-1

Events

***SPECIAL EVENT*** PILOT International Symposium on Perinatal and Early Life Immunity

PILOT will be hosting an International Symposium on Perinatal and Early Life Immunity  from 9-12 April 2025 at the Historisches Kaufhaus in Freiburg

We already have a fantastic line-up of invited speakers for this event. We plan to complement this with talks selected on the basis of abstracts and there will also be opportunities to present posters.

More details will be posted here as they are finalized; in the meantime, please save the date!

 

 

Projects