Markus
Sperandio,
MD Professor
Projects
Research Group Leader
Research Group Leader
Human neonatal CITE-seq atlas identifies an immune transition at 32 weeks’ gestation from CD15⁺ myeloid-dominated to interferon-primed immunityPaula Rothämel, Alessandro Mattia, Maria Isabel Corey, Barbara Puzek, Jana Wiesel, Pauline Michael-Kuschel, Christoph Klein, Markus Sperandio, Philipp Henneke, Claudia Nussbaum, Sarah Kim-Hellmuth 2026 BioRxiv
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Neutrophils are critical for placental and fetal infection with the human pathogen Listeria monocytogenesMyriam Ripphahn, Nikita Raj, Hellen Ishikawa-Ankerhold, Zhouyi Rong, Bastian Popper, Bianca Portugal Tavares de Moraes, Xia Li, Ying Chen, Roland Immler, Lou-Martha Wackerbarth, Dominic van den Heuvel, Barbara Schmidinger, Rainer Haas, Udo Jeschke, Sven Kehl, Anne Loesslein, Steffen Massberg, Farida Hellal, Ali Ertürk, Markus Sperandio 2026 BioRxiv
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Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancyRoland Immler, Wiebke Nadolni, Johanna M Franz, Annika Bertsch, Sebastian Baasch, Vasilios A Morikis, Aleksandra Kurova, Marco Borso, Ignasi Forné, Ericka C M Itang, Johannes B Müller-Reif, Monika Pruenster, Lou M Wackerbarth, Matteo Napoli, Ina Rohwedder, Anna Yevtushenko, Michael Rauer, Martin Kolben, Markus Moser, Eytan Barnea, Melanie Boerries, Thomas Vogl, Scott I Simon, Claudia Klein, Philipp Henneke, Axel Imhof, Susanna Zierler, Markus Sperandio 2026 BioRxiv
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Crosstalk between Stromal cells and Macrophages Shapes Host Immunity to MycobacteriaAnne Kathrin Lösslein, Sebastian Baasch, Leonhard Wagner, Kristina Ritter, Florens Lohrmann, Katja Gräwe, Nisreen Ghanem, Jana Neuber, Alexandra Hölscher, Markus Sperandio, Julia Kolter, Christoph Schell, Roman Sankowski, Sagar, Georg Häcker, Christoph Hölscher, Philipp Henneke 2026 BioRxiv
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Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophilsJohn Ku , Hans-Joachim Anders , Markus Sperandio and Roland Immler 2026 Current Opinion in Immunology
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Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language modelsKaier K, Engel F, Benadi G, Giuliani C, Watter M, Kalantari A, Schuller K, Franzke CW, Sperandio M, Binder H. 2026 BMC Research Notes
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Posttranslational sialylation and its impact on neutrophil recruitmentNussbaumer K, Marth JD, Sperandio M. 2025 Journal of Leukocyte Biology
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Development of a circadian immune system2025 Trends in Immunology
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Neonatal neutrophils exhibit reduced NLRP3 inflammasome activationLou Martha Wackerbarth, Sonja Birke Seifert, Matteo Napoli, Ina Rohwedder, Thomas Vogl, Christoph Scheiermann, Thomas Kolben, Claudia Nussbaum, Monika Pruenster, Roland Immler, Markus Sperandio 2025 Journal of Leukocyte Biology
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Neonatal neutrophils exhibit reduced NLRP3 inflammasome activationLou Martha Wackerbarth, Sonja Birke Seifert, Matteo Napoli, Ina Rohwedder, Thomas Vogl, Christoph Scheiermann, Thomas Kolben, Claudia Nussbaum, Monika Pruenster, Roland Immler, Markus Sperandio 2024 Journal of Leukocyte Biology
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Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammationVíctor Arribas,Yara Onetti, Marina Ramiro-Pareta, Pilar Villacampa, Heike Beck, Mariona Alberola, Anna Esteve-Codina, Angelika Merkel, Markus Sperandio, Ofelia M. Martínez-Estrada, Bettina Schmid, and Eloi Montanez 2024 JCI Insight
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Circadian Clock and HypoxiaFrancesca Sartor, Borja Ferrero-Bordera, Jeffrey Haspel, Markus Sperandio, Paul M Holloway, Martha Merrow 2024 Circulation Research
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CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IVRoland Immler, Katrin Nussbaumer, Axel Doerner, Omar ElBounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A. Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D.Marth, David Frommhold, and Markus Sperandio 2024 PNAS
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Maternal rhythms suppress neonatal inflammation2024 Nature Metabolism
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E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formationMonika Pruenster, Roland Immler, Jonas Roth, Tim Kuchler, Thomas Bromberger, Matteo Napoli, Katrin Nussbaumer, Ina Rohwedder, Lou Martha Wackerbarth, Chiara Piantoni, Konstantin Hennis, Diana Fink, Sebastian Kallabis, Tobias Schroll, Sergi Masgrau-Alsina, Agnes Budke, Wang Liu, Dietmar Vestweber, Christian Wahl-Schott, Johannes Roth, Felix Meissner, Markus Moser, Thomas Vogl, Veit Hornung, Petr Broz & Markus Sperandio 2023 Nature Immunology
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A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogenyRohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. 2023 JCI Insight
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