Impact of neonatal CMV infection on lung macrophage development
We recently discovered that cytomegalovirus (CMV) remodels the identity of fully differentiated alveolar macrophages. This project combines this knowledge with insights into how chronic infections manipulate macrophage progenitors.
We explore how perinatal CMV infections impact on innate cellular barrier immunity. A particular focus is on renewal and function of resident lung macrophage subsets, and thus on immunity to bacterial pneumonia later in life.
Team
Publications
Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in childrenMaximilian Seidl, Elham Bavafaye Haghighi, Anne Kathrin Lösslein, Markus Hufnagel, Florens Lohrmann, Christian Schneider, Daniela S Kohlfürst, Werner Zenz, Gregor Gorkiewicz, Cornelia Feiterna-Sperling, Renate Krüger, Peter Bronsert, Christina Neppl, Kim Zoe Sommer, Verena Stehl, Melanie Boerries, Martin Kuntz, Philipp Henneke 2025 Frontiers in Immunology
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ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNAGreiner-Tollersrud OK, Krausz M, Boehler V, Polyzou A, Seidl M, Spahiu A, Abdullah Z, Andryka-Cegielski K, Dominick FI, Huebscher K, Goschin A, Smulski CR, Trompouki E, Link R, Ebersbach H, Srinivas H, Marchant M, Sogkas G, Staab D, Vågbø C, Guerini D, Baasch S, Latz E, Hartmann G, Henneke P, Geiger R, Peng XP, Grimbacher B, Bartok E, Alseth I, Warncke M, Proietti M. 2025 Cell Reports
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Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interfaceMansoori Moghadam Z, Zhao B, Raynaud C, Strohmeier V, Neuber J, Lösslein AK, Qureshi S, Gres V, Ziegelbauer T, Baasch S, Schell C, Warnatz K, Inohara N, Nunez G, Clavel T, Rosshart SP, Kolter J, Henneke P. 2025 Blood
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Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment |
Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
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