A02

Impact of neonatal CMV infection on lung macrophage development

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Graphical abstract for Project A02 (Figure by M. Rössler)

We recently discovered that cytomegalovirus (CMV) remodels the identity of fully differentiated alveolar macrophages. This project combines this knowledge with insights into how chronic infections manipulate macrophage progenitors.

We explore how perinatal CMV infections impact on innate cellular barrier immunity. A particular focus is on renewal and function of resident lung macrophage subsets, and thus on immunity to bacterial pneumonia later in life.

Team

Publications

Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancy

Roland Immler, Wiebke Nadolni, Johanna M Franz, Annika Bertsch, Sebastian Baasch, Vasilios A Morikis, Aleksandra Kurova, Marco Borso, Ignasi Forné, Ericka C M Itang, Johannes B Müller-Reif, Monika Pruenster, Lou M Wackerbarth, Matteo Napoli, Ina Rohwedder, Anna Yevtushenko, Michael Rauer, Martin Kolben, Markus Moser, Eytan Barnea, Melanie Boerries, Thomas Vogl, Scott I Simon, Claudia Klein, Philipp Henneke, Axel Imhof, Susanna Zierler, Markus Sperandio

Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children

Maximilian Seidl, Elham Bavafaye Haghighi, Anne Kathrin Lösslein, Markus Hufnagel, Florens Lohrmann, Christian Schneider, Daniela S Kohlfürst, Werner Zenz, Gregor Gorkiewicz, Cornelia Feiterna-Sperling, Renate Krüger, Peter Bronsert, Christina Neppl, Kim Zoe Sommer, Verena Stehl, Melanie Boerries, Martin Kuntz, Philipp Henneke 

2025 Frontiers in Immunology

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA

Greiner-Tollersrud OK, Krausz M, Boehler V, Polyzou A, Seidl M, Spahiu A, Abdullah Z, Andryka-Cegielski K, Dominick FI, Huebscher K, Goschin A, Smulski CR, Trompouki E, Link R, Ebersbach H, Srinivas H, Marchant M, Sogkas G, Staab D, Vågbø C, Guerini D, Baasch S, Latz E, Hartmann G, Henneke P, Geiger R, Peng XP, Grimbacher B, Bartok E, Alseth I, Warncke M, Proietti M.