Mathias Hornef

Mathias Hornef

Mathias
Hornef,
MD Professor

mhornef@ukaachen.de

Project leader

Steering Committee

Projects

RWTH University Aachen

RWTH University Hospital Aachen

Institute of Medical Microbiology

Head of the Institute of Medical Microbiology

PILOT Publications

A01 A07 A03 A06 Neonatal liver niches program T cell tolerance Eva-Lena Stange, Trong-Hieu Nguyen, Dustyn Mendoza, Aiara Lobo Gomes, Marlene Sophia Kohlhepp, Jonas Pes, Shahed Al Bounny, Julian Brueck, Yunus Cetiner, Urs Moerbe, Milas Ugur, Cristina Kalbermatter, Jarrett Lopez-Scarim, Aline Dupont, Susan A. V. Jennings, Julia Heckmann, Aaron Silva-Sanchez, Solveig Runge, Christoph Kuppe, Oliver Pabst, Thomas Clavel, Dorothee Viemann, Stephan P. Rosshart, Vuk Cerovic, Stephanie C. Ganal-Vonarburg, Adrien Guillot, Eva Billerbeck, Mathias W. Hornef, Natalia Torow 2026 BioRxiv https://www.biorxiv.org/content/10.64898/2026.01.13.698576v1
B05 A01 RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells Hamsa Narasimhan, Maria L. Richter, Ramin Shakiba, Nikos E. Papaioannou, Christina Stehle, Kaushikk Ravi Rengarajan, Isabel Ulmert, Arek Kendirli, Clara de la Rosa, Pin-Yu Kuo, Abigail Altman, Philipp Münch, Saba Mahboubi, Vanessa Küntzel, Amina Sayed, Eva-Lena Stange, Jonas Pes, Alina Ulezko Antonova, Carlos-Filipe Pereira, Ludger Klein, Diana Dudziak, Marco Colonna, Natalia Torow, Mathias W. Hornef, Björn E. Clausen, Martin Kerschensteiner, Katharina Lahl, Chiara Romagnani, Maria Colomé-Tatché, and Barbara U. Schraml 2025 PNAS https://doi.org/10.1073/pnas.2417308122
A01 A06 Salmonella infection accelerates postnatal maturation of the intestinal epithelium Stefan Schlößer, Anna-Lena Ullrich, Nastaran Fazel Modares, Matthias A. Schmitz, Johannes Schöneich, Kaiyi Zhang, Isabel Richter, Laura Robrahn, Sarah Schraven, James S. Nagai, Sven-Bastiaan Haange, Susan A. V. Jennings, *Thomas Clavel, Ulrike Rolle-Kampczyk, Fabian Kiessling, Ivan G. Costa, Vanesa Muncan, Urska Repnik, Martin von Bergen, Aline Dupont, and Mathias W. Hornef* 2024 PNAS https://doi.org/10.1073/pnas.2403344122
A01 A05 Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes Mangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen, Andrea Leufgen, Vuk Cerovic, Carolin Wiechers, Marina Pils, Diego Ortiz, Lianxu Hao, Juhao Yang, Michael Beckstette, Aline Dupont, Mathias Hornef, Petra Dersch, Till Strowig, Andreas J. Müller, Jens Raila, Jochen Huehn 2024 Cell Reports https://doi.org/10.1016/j.celrep.2024.114153
A01 Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host Kaiyi Zhang, Urska Repnik, Nour Diab, Daniel Friske, Andreas Pütz, Alina Z. Bachmann, Narasimha Murthy Keshava Prasad Gubbi1, Michael Hensel, Konrad U. Förstner, Alexander J. Westermann, Aline Dupont, and Mathias W. Hornef 2024 Journal of Experimental Medicine https://rupress.org/jem/article/221/3/e20231237/276543/Non-professional-efferocytosis-of-Salmonella
A01 Programmed and environmental determinants driving neonatal mucosal immune development Natalia Torow, Timothy W. Hand, Mathias W. Hornef 2023 Immunity https://www.sciencedirect.com/science/article/pii/S1074761323000870?via%3Dihub=#sec7
A01 A06 A07 M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch Torow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW 2023 Immunity https://doi.org/10.1016/j.immuni.2023.04.002