B06
Genetic regulation of protein expression during immune cell development in human neonates
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Our project investigates the role of cis-regulatory genetic variants on blood protein expression during perinatal immune cell development in human neonates. To do this, we use the Munich Preterm and Term clinical (MUNICH-PreTCl) birth cohort.
As well as mass spectrometry-based blood proteomes, we will generate genome-wide genotypes of single nucleotide polymorphisms for proteomic in silico cell type deconvolution of the human neonatal immune system with a focus on neutrophils.
Team
Publications
A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogenyRohwedder I, Wackerbarth LM, Heinig K, Ballweg A, Altstätter J, Ripphahn M, Nussbaum C, Salvermoser M, Bierschenk S, Straub T, Gunzer M, Schmidt-Supprian M, Kolben T, Schulz C, Ma A, Walzog B, Heinig M, Sperandio M. 2023 JCI Insight
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