Effects of neonatal wildling microbiota on the immune response to vaccination
In this project, we study the impact of the microbiota on the neonatal vaccine-induced germinal center reaction. The proposal is based on our fundamental discoveries that “wildling” mouse microbiota tune systemic immunity in a way that better reflects human immune responses than microbiota found under specific-pathogen-free conditions.
The project explores the impact of wild microbiota 1) on the capacity of dendritic cells from young mice to mediate T cell help in influenza infections and 2) on vaccination.
Team
Publications
Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infectionTommaso Torcellan, Christin Friedrich, Rémi Doucet-Ladevèze, Thomas Ossner, Virgínia Visaconill Solé, Sofie Riedmann, Milas Ugur, Fabian Imdahl, Stephan P. Rosshart, Sebastian J. Arnold, Mercedes Gomez de Agüero, Nicola Gagliani, Richard A. Flavell, Simone Backes, Wolfgang Kastenmüller, Georg Gasteiger 2024 Immunity
|
GenIA, the Genetic Immunology Advisor database for inborn errors of immunityAndrés Caballero-Oteyza PhD, Laura Crisponi, Xiao P. Peng, Kevin Yauy, Stefano Volpi, Stefano Giardino, Alexandra F. Freeman, Bodo Grimbacher, Michele Proietti 2024 Journal of Allergy and Clinical Immunology
|
Laboratory mice with a wild microbiota generate strong allergic immune responsesMa J, Urgard E, Runge S, Classon CH, Mathä L, Stark JM, Cheng L, Álvarez JA, von Zedtwitz S, Baleviciute A, Martinez Hoyer S, Li M, Gernand AM, Osbelt L, Bielecka AA, Lesker TR, Huang HJ, Vrtala S, Boon L, Beyaert R, Adner M, Martinez Gonzalez I, Strowig T, Du J, Nylén S, Rosshart SP, Coquet JM. 2023 Science Immunol
|
Impact of High Salt-Intake on a Natural Gut Ecosystem in Wildling MiceCardilli A, Hamad I, Dyczko A, Thijs S, Vangronsveld J, Müller DN, Rosshart SP, Kleinewietfeld M. 2023 Nutrients
|
Human resident liver myeloid cells protect against metabolic stress in obesityBarreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallett LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P, Aouadi M. 2023 Nat Metab
|
M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patchTorow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW 2023 Immunity
|