People
Publications
Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression
Nour Diab, Chiun Huei Yong, Eva-Lena Stange, Marlène S. Birk, Matthias A. Schmitz, Stefan Düsterhöft, Jonas Pes, Kira Noemi Ferle, Isabel Karkossa, Kristin Schubert, Jörg Deiwick, Mihael Vucur, Tom Luedde, Natalia Torow, Andreas Ludwig, Aline Dupont, Joel Selkrig, Martin von Bergen, Michael Hensel, Kaiyi Zhang & Mathias W. Hornef
Developmental factors drive the compartmentalized and discontinuous maturation of the small intestinal epithelium during the early postnatal period
Johannes Schöneich, Aline Dupont, Stefan Schlößer, Mingbo Cheng,
Matthias A. Schmitz, Isabel Richter, Narasimha Murthy Keshava Prasad Gubbi,
Kaiyi Zhang, Tiago Maié, Asmae Laouina, Sofia Jäverfelt, Fabian Imdahl,
Christophe Toussaint, Antoine-Emmanuel Saliba, Christoph Kuppe, Oliver Pabst,
Thaher Pelaseyed, Ivan G. Costa, Mathias W. Hornef
Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation
Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria L. Richter, Maria Parra Reyes, Nadine Nuschele, Denise Messerer, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas, Melanie Schmid, Tobias Straub, Michele Proietti, Katrin Böttcher, Maria Colomé-Tatché, Dirk Haller, Jan P. Böttcher, Stephanie Ganal-Vonarburg, Sophie Janssens, Christian Schulz, Anne B. Krug, Barbara U. Schraml
Mixed feeding and mode of birth modulate the effects of a hydrolyzed synbiotic formula on the gut microbiome in infants at risk of atopic disease
Intze E, Schaubeck M, Arendt BM, Fleddermann M, Beyer K, Clavel T, Lagkouvardos I, Hitch TCA
Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis
Mayer LS, Arnold J, Roettele F, Reuter N, Pattekar A, Ohtani T, Ribeiro MM, Siwicki R, Bruder K, Obwegs D, Stahl E, Buechel S, Roehlen N, Kolter J, Mansoori Moghadam Z, Alaswad A, Zhumalidova Z, Li G, Liu X, Li Y, Singh A, Villacorta Hidalgo J, Paraskevopoulou MD, Yajnik V, Juarez J, Ren Y, Li H, Wherry EJ, Lewis JD, Wu GD, Bewtra M, Tomov VT, Thimme R, Bengsch B, Hasselblatt P, Picelli S, Hofmann M, Sagar
Macrophage renewal in the small intestine governs early-life control of streptococci
Zohreh Mansoori Moghadam, Mirjam Freudenhammer, Maria Francesca Viola, Marleen Eckert, Candice Raynaud, Linus Kriegl, Michael Rauer, Reem Alsumati, Nicole Treichel, Ramona Rebekka Eckert, Sebastian Baasch, Melanie Boerries, Elvira Mass, Thomas Clavel, Daniel Erny, Julia Kolter, Philipp Henneke
The infant microbiota hopscotches between community states toward maturation—longitudinal stool parameters and microbiota development in a cohort of European toddlers
Intze E, Schaubeck M, Pourjam M, Neuhaus K, Lagkouvardos I, Hitch TCA, Clavel T.
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells
Hamsa Narasimhan, Maria L. Richter, Ramin Shakiba, Nikos E. Papaioannou, Christina Stehle, Kaushikk Ravi Rengarajan, Isabel Ulmert, Arek Kendirli, Clara de la Rosa, Pin-Yu Kuo, Abigail Altman, Philipp Münch, Saba Mahboubi, Vanessa Küntzel, Amina Sayed, Eva-Lena Stange, Jonas Pes, Alina Ulezko Antonova, Carlos-Filipe Pereira, Ludger Klein, Diana Dudziak, Marco Colonna, Natalia Torow, Mathias W. Hornef, Björn E. Clausen, Martin Kerschensteiner, Katharina Lahl, Chiara Romagnani, Maria Colomé-Tatché, and Barbara U. Schraml
Postnatal supplementation with alarmins S100a8/a9 ameliorates malnutrition-induced neonate enteropathy in mice
Perruzza L, Heckmann J, Rezzonico Jost T, Raneri M, Guglielmetti S, Gargari G, Palatella M, Willers M, Fehlhaber B, Werlein C, Vogl T, Roth J, Grassi F, Viemann D
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
Stefan Schlößer, Anna-Lena Ullrich, Nastaran Fazel Modares, Matthias A. Schmitz, Johannes Schöneich, Kaiyi Zhang, Isabel Richter, Laura Robrahn, Sarah Schraven, James S. Nagai, Sven-Bastiaan Haange, Susan A. V. Jennings, Thomas Clavel, Ulrike Rolle-Kampczyk, Fabian Kiessling, Ivan G. Costa, Vanesa Muncan, Urska Repnik, Martin von Bergen, Aline Dupont, and Mathias W. Hornef
Maternal rhythms suppress neonatal inflammation
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host
Kaiyi Zhang, Urska Repnik, Nour Diab, Daniel Friske, Andreas Pütz, Alina Z. Bachmann, Narasimha Murthy Keshava Prasad Gubbi1, Michael Hensel, Konrad U. Förstner, Alexander J. Westermann, Aline Dupont, and Mathias W. Hornef
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
Anastasia du Halgouet, Kerstin Bruder, Nina Peltokangas, Aurélie Darbois, David Obwegs, Marion Salou, Robert Thimme, Maike Hofmann, Olivier Lantz & Sagar
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallett LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P, Aouadi M.
M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch
Torow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW
Artikel
New publication that intrauterine inflammation impacts neonatal dendritic cell development and function (PNAS)
A new publication in PNAS - co-authored by 5 PILOT members - has shown that a particular…
New Publication in Nature Communications by PILOT member Dorothee Viemann
PILOT member Dorothee Viemann has published a new paper in Nature Communications:…
New PILOT publication by B06
PILOT members Claudia Nussbaum and Sarah Kim-Hellmuth published a new article in Cell…
New paper from PILOT member Sagar
Unlocking the Intricacies of Gamma-Delta T Cells
Gamma-delta T cells represent a…
New paper from PILOT members Hornef, Clavel and Rosshart
PILOT members including Mathias Hornef, Tom Clavel and Stephan Rosshart have recently published…
Events
***SPECIAL EVENT*** PILOT International Symposium on Perinatal and Early Life Immunity
PILOT will be hosting an International Symposium on Perinatal and Early Life Immunity from 9-12 April 2025 at the Historisches Kaufhaus in Freiburg
We already have a fantastic line-up of invited speakers for this event. We plan to complement this with talks selected on the basis of abstracts and there will also be opportunities to present posters.
More details will be posted here as they are finalized; in the meantime, please save the date!